The CIS Variant feature in Part Manager is your friend. Especially with "Variant View" that can highlight affected parts (might want to change the gray color to something more visible.) CIS allows you to assign and remove parts from CIS Groups while editing the schematic (you won't have to keep part manager open all the time.) We use groups to manage and verify NoLoad vs. placed parts. When changing the status, add the part to the load group but remember to take it out of the previous group first or you get an ambiguous error (one entry says load it, other entry conflicts.)
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